Cytotoxic and COX-2 Inhibition Properties of Hydroxycinnamic Derivatives

Author(s): M. Paula M. Marques , Fernanda Borges , Joana Sousa , Rita Calheiros , Jorge Garrido , Alexandra Gaspar , Carmen Diniz , Paula Fresco .

Journal Name: Letters in Drug Design & Discovery

Volume 3 , Issue 5 , 2006

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The anticancer (cytotoxicity against human mammary gland adenocarcinoma cells) and antiinflammatory properties (COX-2 inhibition) of the hydroxycinnamic derivatives trans-3-(3,4,5- trihydroxyphenyl)-2-propenoic acid, trans-ethyl(3,4,5-trihydroxyphenyl)-2-propenoate and diethyl 2-(3,4,5- trihydroxy-phenylmethylene)malonate were screened. Data point out a putative correlation between antiinflammatory and anticancer properties and suggest hydroxycinnamic derivatives as promising lead compounds for the development of anti-inflammatory/chemopreventive agents.

Keywords: Hydroxycinnamic derivatives, anti-inflammatory, COX-2, anticancer, mammary gland adenocarcinoma cells

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Article Details

Year: 2006
Page: [316 - 320]
Pages: 5
DOI: 10.2174/157018006777574212
Price: $58