Target Structure-based Modeling of the Glutamate Transporter Pharmacophore

Author(s): A. Simon , A. Bencsura , J. Kardos .

Journal Name: Letters in Drug Design & Discovery

Volume 3 , Issue 5 , 2006

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Abstract:

Comparison of binding interactions of a bacterial Glu transporter homologue and the extracellular binding domain of metabotropic Glu receptor subtype (mGlu1) showed Glu adopting bent and extended conformations in Glu transporter and mGlu1, respectively.

Keywords: Glutamate transporter, metabotropic Glu receptor subtype 1, docking and molecular dynamics, glutamate, L-trans-2, 4-PDC, GABA

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Article Details

VOLUME: 3
ISSUE: 5
Year: 2006
Page: [293 - 297]
Pages: 5
DOI: 10.2174/157018006777574230
Price: $58