Determination of Mutation Trend in Hemagglutinins by Means of Translation Probability Between RNA Codons and Mutated Amino Acids

Author(s): Guang Wu, Shaomin Yan.

Journal Name: Protein & Peptide Letters

Volume 13 , Issue 6 , 2006

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Abstract:

In this study, we used the 183 translation probabilities between RNA codons and mutated amino acids to construct the theoretical distributions of mutated amino acids in hemagglutinins of influenza A virus. We then compared the actual distributions of mutated amino acids from 953 hemagglutinins with their theoretical ones. The results demonstrated that mutated amino acids generally follow the direction of the theoretical distributions governed by RNA codons. This, in turn, highlights the mutation trend of amino acids in hemagglutinins and provides a method for estimating possible mutations in a protein according to its theoretical distributions of mutated amino acids.

Keywords: Hemagglutinin, influenza, mutation, RNA, translation probability

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Article Details

VOLUME: 13
ISSUE: 6
Year: 2006
Page: [601 - 609]
Pages: 9
DOI: 10.2174/092986606777145779
Price: $58

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