The Prediction of Hydrophobicity Gradients within Membrane Interactive Protein α-Helices Using a Novel Graphical Technique

Author(s): Frederick Harris, Sarah Dennison, David A Phoenix.

Journal Name: Protein & Peptide Letters

Volume 13 , Issue 6 , 2006

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Abstract:

Here, it is shown that amphiphilicity profiling based on the mean hydrophobic moment provides a simple visual guide for the identification of oblique orientated a-helices. The methodology has an efficiency of circa 70% and predicts that approximately 40% of transmembrane a-helices may possess these structures.

Keywords: Oblique orientated α-helix, hydrophobicity gradient, hydropathy plot analysis, hydrophobic moment, amphiphilic profiling, transmembrane protein

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Article Details

VOLUME: 13
ISSUE: 6
Year: 2006
Page: [595 - 600]
Pages: 6
DOI: 10.2174/092986606777145832
Price: $58

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