Juxtaposed Half-Cystines as Disulphide Bridged Partners in Protein Tertiary Structure

Author(s): Kunchur Guruprasad, V. J. Kartik, T. Lavanya, Lalitha Guruprasad.

Journal Name: Protein & Peptide Letters

Volume 13 , Issue 6 , 2006

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Disulphide bridges involving juxtaposed half-cystines are observed in a number of protein three-dimensional structures analyzed from the Protein Data Bank. These disulphide bridges comprise a ring of 8-atoms corresponding to Cα1-C-N-Cα2-Cβ2-Sγ2-Sγ1-Cβ1-Cα1 in the two half-cystines. The presence of such disulphide bridges introduces a bend or kink in the protein polypeptide chain.

Keywords: Protein Data Bank (PDB), Disulphide Bridges, neurotoxin, Cys83, oxidoreductases

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Article Details

Year: 2006
Page: [577 - 579]
Pages: 3
DOI: 10.2174/092986606777145841
Price: $58

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