Coagulation and Sepsis

Author(s): F. R. Machado, E. Silva.

Journal Name: Endocrine, Metabolic & Immune Disorders - Drug Targets

Volume 6 , Issue 2 , 2006

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Abstract:

Sepsis is a complex disease and coagulation derangements are part of this context. The inflammatory storm is ultimately responsible for coagulation derangements. It is characterized by exacerbated coagulation, impaired anticoagulation and decreased fibrin removal. These derangements are implicated in the generation of microcirculation thrombosis, with deposition of microclots and obstruction of circulation, impairing blood flow and contributing to tissue hypoperfusion and consequently, organ dysfunction. This review will address the main issues regarding coagulation disorders in the context of sepsis.

Keywords: Sepsis, coagulation, fibrinolysis, activated protein C, antithrombin, tissue factor

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Article Details

VOLUME: 6
ISSUE: 2
Year: 2006
Page: [175 - 182]
Pages: 8
DOI: 10.2174/187153006777442369
Price: $58