NR2B Selective NMDA Antagonists: The Evolution of the Ifenprodil-Type Pharmacophore

Author(s): Istvan Borza , Gyorgy Domany .

Journal Name: Current Topics in Medicinal Chemistry

Volume 6 , Issue 7 , 2006

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Abstract:

The quest for NR2B subtype selective NMDA antagonists started almost twenty years ago. The structure of ifenprodil, the prototype of this group of compounds, inspired many medicinal chemists in several research units. Different approaches led to the identification of the pharmacophore and several distinct classes of compounds containing this pharmacophore. From these studies a few drug candidates emerged and clinical trials proved the viability of the concept. This article attempted to follow the evolution from ifenprodil, a multiple ligand, to selective NR2B antagonists.

Keywords: Ifenprodil, NR2B subunit, pharmacophore, side activities, piperidines

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Article Details

VOLUME: 6
ISSUE: 7
Year: 2006
Page: [687 - 695]
Pages: 9
DOI: 10.2174/156802606776894456
Price: $58

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