Proteome Analysis of Resting Human Neutrophils

Author(s): Mariana d. S. Castro, Natan M. de Sa, Renata P. Gadelha, Marcelo V. de Sousa, Carlos A. O. Ricart, Belchor Fontes, Wagner Fontes.

Journal Name: Protein & Peptide Letters

Volume 13 , Issue 5 , 2006

Abstract:

Neutrophils constitute the first line of host defense against pathogens. In the present study 2-D gel electrophoresis- mass spectrometry technology was employed to analyze the human resting neutrophils proteome. One hundred and two conserved spots were subjected to peptide mass fingerprinting, yielding 22 identifications. Among the identified proteins, nine are related to the inflammatory process, two polypeptides are assigned to metabolic functions and five are classified as structural.

Keywords: Neutrophils, proteome, peptide mass fingerprinting, inflammatory response

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Article Details

VOLUME: 13
ISSUE: 5
Year: 2006
Page: [481 - 487]
Pages: 7
DOI: 10.2174/092986606776819529
Price: $58

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