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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Novel Anti-Viral Therapy: Drugs that Block HIV Entry at Different Target Sites

Author(s): Sandra Siegert, Peter Schnierle and Barbara S. Schnierle

Volume 6, Issue 5, 2006

Page: [557 - 562] Pages: 6

DOI: 10.2174/138955706776876267

Price: $65

Abstract

Drugs that block the entry of human immunodeficiency virus type 1 (HIV-1) into host cells abrogate the establishment of a productive infection and should ideally diminish the chances of HIV-1 developing resistance. This review will give an overview of the mechanism by which the envelope glycoprotein mediates HIV-1 entry and will summarize current drug developments.

Keywords: HIV, entry, inhibitor


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