Alternative Albendazole Polybutylcyanoacrylate Nanoparticles Preparation, Pharmaceutical Properties and Tissue Distribution in Rats
Two loaded nanoparticles, albendazole polybutylcyanoacrylate nanoparticles (ABZ-PBCA-NP) and albendazole polyvinylpyrrolidone. Polybutylcyanoacrylate nanoparticles (ABZ-PVP-PBCA-NP) were prepared by the emulsification-polymerization method. Tissue distribution and tissue targeting of ABZ-PBCA-NP in mice was studied. The drug-load mechanism of ABZ-PBCA-NP was studied by the equal-temperature absorption principle. The drug loaded in nanoparticle was coincident with the Langmuir adsorption equation. The dialyzed dynamic of albendazole from four formulations, ABZ-PBCA-NP, PVP-ABZ-PBCA-NP, ABZ suspension (SABZ) and ABZ liquid (LABZ), was investigated in vitro. ABZ-PBCA-NP and PVP-ABZ-PBCA-NP were suitable for the Higuchi and bi-exponent function respectively. The absorptive capability of the drug was enhanced when 4% PVP was added into the nanoparticle, and its release time was increased. The tissue distribution of albendazole in different drug vehicles was studied by isotope labeling experiment. Targeting index of albendazole in liver and spleen in mice was estimated at 11.4 and 3.9 after ig 3H-ABZ-PBCA-NP. The bioavailability of albendazole nanoparticle and suspension was 76.0% and 36.9%, respectively. The results have shown that the nanoparticle vehicles increase the albendazole bioavailability.
Keywords: Albendazole nanoparticles, targeting index, tissue distribution, bioavailability, pharmacokinetics
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