Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Hologram QSAR Studies on Farnesoid X Receptor Activators

Author(s): Kathia M. Honorio, Richard C. Garratt, Igor Polikarpov, Adriano D. Andricopulo.

Abstract:

Farsenoid X receptor (FXR) is an attractive drug target due to its role in the regulation of cholesterol and bile acid levels. Hologram quantitative structure-activity relationships (HQSAR) were conducted on a series of FXR activators, and the final model obtained was used to predict the potency of 10 test set compounds. The predicted values were in good agreement with the experimental results.

Keywords: HQSAR, drug design, FXR, medicinal chemistry, cholesterol

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Article Details

VOLUME: 3
ISSUE: 4
Year: 2006
Page: [261 - 267]
Pages: 7
DOI: 10.2174/157018006776743206
Price: $58