Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Targeting the Epigenome in Hematopoietic Malignancies

Author(s): E. Jost, R. Osieka, O. Galm.

Abstract:

Two epigenetic events that are associated with transcriptional silencing in carcinogenesis include hypermethylation of CpG islands near gene promoter regions and changes in chromatin conformation involving histone acetylation. Pharmacologic targeting of these epigenetic processes and upregulation of genes involving fundamental cellular pathways have become a new therapeutic strategy in the treatment of hematopoietic malignancies.

Keywords: Epigenetics, DNA methylation, histone modifications, transcriptional silencing, tumor suppressor genes

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Article Details

VOLUME: 3
ISSUE: 4
Year: 2006
Page: [242 - 252]
Pages: 11
DOI: 10.2174/157018006776743251
Price: $58