Current Pediatric Reviews

Giuseppe Buonocore
Department of Molecular and Developmental Medicine
University of Siena
Siena
Italy

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Cellular Mechanisms in Perinatal Hypoxic-Ischemic Brain Injury

Author(s): Enrique Hilario, Antonia Alvarez, Francisco J. Alvarez, Elena Gastiasoro, Adolf Valls-i-Soler.

Abstract:

Hypoxia-ischemia is responsible for a high morbidity and mortality rate, both in infant and adult patients. In humans, the brain is immature from fetal to postnatal life, demonstrating more specific vulnerability than the adult one, induced by exposure at perinatal asphyxia. The extension and distribution of brain lesions depend to a large extent on the intensity and exposure to injury, the maturational stage, the affected brain region and the survival time of the patient. Different cellular events are developed in response to hypoxic-ischemic injury. These events have been related to the excitotoxicity (activation of glutamate receptors), energy failure (decrease in ATP levels), inflammatory cascade (delivery of inflammatory mediators), and gene and transcriptional activation.

Keywords: Hipoxia-Ischemia, Perinatal asphyxia, Brain damage, Excitotoxicity

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Article Details

VOLUME: 2
ISSUE: 2
Year: 2006
Page: [131 - 141]
Pages: 11
DOI: 10.2174/157339606776894667
Price: $58