Leukocyte Function-Associated Antigen-1: Structure, Function and Application Prospects

Author(s): Ma Xingyuan , Zheng Wenyun , Wang Tianwen .

Journal Name: Protein & Peptide Letters

Volume 13 , Issue 4 , 2006

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Abstract:

This review focuses on the structure, function and pathological role of leukocyte function-associated antigen-1 (LFA-1) which is a heterodimeric protein consisting of two subunits. LFA-1 plays a most important role in the immune system including adhesion, extravasation, migration, apoptosis, cytotoxicity, cytokine production, and proliferation of lymphocytes. Therefore, T-cell activation can be suppressed by blocking ICAM-1/LFA-1 interaction in autoimmune diseases and organ transplantation. Many different inhibitors (i.e. antibodies, peptides, small molecules) have been demonstrated to block ICAM-1/LFA-1 interaction, and some of them are promising for medical treatment or have reached clinical trials.

Keywords: LFA-1, structure, function, pathological role, drug designing

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Article Details

VOLUME: 13
ISSUE: 4
Year: 2006
Page: [397 - 400]
Pages: 4
DOI: 10.2174/092986606775974429
Price: $58

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