Rho-Kinase as a Drug Target for the Treatment of Airway Hyperresponsiveness in Asthma

Author(s): Reinoud Gosens , Dedmer Schaafsma , S. A. Nelemans , Andrew J. Halayko .

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 6 , Issue 3 , 2006

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Abstract:

In asthma, inflammatory and structural cells contribute to increased bronchoconstriction acutely and more chronically to airway remodelling. Current asthma therapy doesnt inhibit these features satisfactorily. This review discusses Rho-kinase as a potential drug target, since increasing evidence suggests a central role for this pathway in acute and chronic airway hyperresponsiveness.

Keywords: Airway remodelling, airway smooth muscle, airway inflammation, Y-27632, fasudil

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Article Details

VOLUME: 6
ISSUE: 3
Year: 2006
Page: [339 - 348]
Pages: 10
DOI: 10.2174/138955706776073402
Price: $58