Effects of the Natural Isoflavonoid Genistein on Growth, Signaling Pathways and Gene Expression of Matrix Macromolecules by Breast Cancer Cells

Author(s): O. C. Kousidou, G. N. Tzanakakis, N. K. Karamanos.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 6 , Issue 3 , 2006

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Abstract:

Genistein is a well known protein tyrosine kinase inhibitor. It is structurally similar to 17- estradiol and exerts antiestrogenic effects. It also affects the signal transduction components Akt, FAK, ErbB-2 and Bcl-2. Key enzymes implicated in cancer invasion are also affected by genistein. A critical evaluation of the effects of genistein on breast cancer growth, signaling and gene expression is presented in this review.

Keywords: genistein, estrogens, estrogen receptor, signaling, breast cancer

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Article Details

VOLUME: 6
ISSUE: 3
Year: 2006
Page: [331 - 337]
Pages: 7
DOI: 10.2174/138955706776073420
Price: $58