Cardiovascular Disease in Diabetes

Author(s): Sho-ichi Yamagishi, Kazuo Nakamura, Takanori Matsui, Katsuhiko Takenaka, Yuko Jinnouchi, Tsutomu Imaizumi.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 6 , Issue 3 , 2006

Become EABM
Become Reviewer

Abstract:

Diabetes is associated with a marked increase in the risk of atherosclerotic vascular disorders, including coronary, cerebrovascular, and peripheral artery disease. Cardiovascular disease (CVD) could account for disabilities and high mortality rates in patients with diabetes. In this paper, we review the molecular mechanisms for accelerated atherosclerosis in diabetes, especially focusing on postprandial hyperglycemia, advanced glycation end products (AGEs) and the renin-angiotensin system. We also discuss here the potential therapeutic strategy that specifically targets CVD in patients with diabetes.

Keywords: AGEs, atherosclerosis, diabetes, oxidative stress, renin-angiotensin system

Rights & PermissionsPrintExport Cite as


Article Details

VOLUME: 6
ISSUE: 3
Year: 2006
Page: [313 - 318]
Pages: 6
DOI: 10.2174/138955706776073501
Price: $58

Article Metrics

PDF: 2