Microcystin Produces Disparate Effects on Liver Cells in a Dose Dependent Manner

Author(s): Lars Herfindal, Frode Selheim.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 6 , Issue 3 , 2006

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Abstract:

In this review we present recent studies on the effects of the protein phosphatase inhibitor microcystin on mammalian cells. Whereas high concentrations of microcystin promote liver cell death induced by ROS signalling without the involvement of typical apoptotic proteins, intermediate doses activate classic apoptotic pathways. Low concentrations however, increase liver cell survival and proliferation, and can cause primary liver cancer.

Keywords: Microcystin, protein phosphatases, PP1, PP2A, reactive oxygen species, cancer, apoptosis, mitochondria

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Article Details

VOLUME: 6
ISSUE: 3
Year: 2006
Page: [279 - 285]
Pages: 7
DOI: 10.2174/138955706776073475
Price: $58

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