Interactions of Chemicals and Metal Ions with Proteins and Role for Immune Responses

Author(s): Stefan F. Martin , Irmgard Merfort , Hermann-Josef Thierse .

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 6 , Issue 3 , 2006

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Abstract:

Chemicals and metal ions often induce allergic contact dermatitis. We review here recent advances in the development of in vitro assays for prediction of skin sensitizing potency based on chemical and biological reactivity as well as in the identification of physiological binding partners and immunological pathomechanisms of chemical and metal ion induced disease.

Keywords: Allergic contact dermatitis, skin sensitization, chemical, metalion, hapten, arnica, nickel, proteomics

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Article Details

VOLUME: 6
ISSUE: 3
Year: 2006
Page: [247 - 255]
Pages: 9
DOI: 10.2174/138955706776073493
Price: $58

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