Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Synthesis and Biological Activity of New 4β-N-Heteroaryl Analogues of Podophyllotoxin

Author(s): Ahmed Kamal, B. A. Kumar, M. Arifuddin, Sunanda G. Dastidar.

Abstract:

Some new 4β-N-heteroaryl analogues of podophyllotoxin have been prepared by employing Red Phosphorous/I2 reagent system. These 4β-N-heteroaryl analogues have been evaluated for their cytotoxicity against six human cancer cell lines and some representative ones have shown promising anticancer activity.

Keywords: Epipodophyllotoxin, benzothiazoles, pyrimidines, anticancer activity

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Article Details

VOLUME: 3
ISSUE: 3
Year: 2006
Page: [205 - 209]
Pages: 5
DOI: 10.2174/157018006776286907
Price: $58