Increasing the Odds of Drug Hit Identification by Screening Against Receptor Homologs?

Author(s): Z. L. Ji , Z. R. Li , J. F. Wang , C. Z. Cai , L. Y. Han , C. J. Zheng , Y. Z. Chen .

Journal Name: Letters in Drug Design & Discovery

Volume 3 , Issue 3 , 2006

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Abstract:

The odds of drug hit identification in screening are closely related to the diversity of libraries or the availability of focused libraries. There are no truly diverse libraries and it is difficult to design focused libraries without sufficient information. Hence alternative approaches need to be explored for enhancing the odds of hit discovery from existing libraries. Protein homologs have been used collectively targeted in inhibitor design and other discovery applications by exploiting the correlation between protein homologs and their ligands from specific compound classes. A receptor-homolog-based screening scheme may be derived as a strategy to potentially increase the odds of hit identification.

Keywords: Drug design, drug discovery, high throughput screening, homologs, virtual screening

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Article Details

VOLUME: 3
ISSUE: 3
Year: 2006
Page: [200 - 204]
Pages: 5
DOI: 10.2174/157018006776286970
Price: $58