Increasing the Odds of Drug Hit Identification by Screening Against Receptor Homologs?

Title: Increasing the Odds of Drug Hit Identification by Screening Against Receptor Homologs?

Volume: 3 Issue: 3

Author(s): Z. L. Ji, Z. R. Li, J. F. Wang, C. Z. Cai, L. Y. Han, C. J. Zheng and Y. Z. Chen

Affiliation:

Keywords: Drug design, drug discovery, high throughput screening, homologs, virtual screening

Abstract: The odds of drug hit identification in screening are closely related to the diversity of libraries or the availability of focused libraries. There are no truly diverse libraries and it is difficult to design focused libraries without sufficient information. Hence alternative approaches need to be explored for enhancing the odds of hit discovery from existing libraries. Protein homologs have been used collectively targeted in inhibitor design and other discovery applications by exploiting the correlation between protein homologs and their ligands from specific compound classes. A receptor-homolog-based screening scheme may be derived as a strategy to potentially increase the odds of hit identification.

Cite this article as:

Ji L. Z., Li R. Z., Wang F. J., Cai Z. C., Han Y. L., Zheng J. C. and Chen Z. Y., Increasing the Odds of Drug Hit Identification by Screening Against Receptor Homologs?, Letters in Drug Design & Discovery 2006; 3 (3) . https://dx.doi.org/10.2174/157018006776286970