Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
Email: lddd@benthamscience.org


Preparation of a Cyclodextrin Conjugated With Two Arbutin Moieties as a Drug-Carrier Model, and its High Ability for the Inclusion of Doxorubicin

Author(s): Takashi Yamanoi, Natsumi Kobayashi, Keiko Takahashi, Kenjiro Hattori.


Cyclodextrin derivatives conjugated with one or more saccharide moieties are expected to be useful as targeted drug-delivery systems. We prepared a cyclodextrin conjugated with two arbutin moieties, which was designed as a model for a drug carrier having a high ability for the inclusion of the anticancer agent doxorubicin. Studies using a surface plasmon resonance optical biosensor showed that the cyclodextrin derivative has an extremely high association constant of 1.4 10 8 M-1 for immobilized doxorubicin.

Keywords: Cyclodextrin, drug-delivery system, drug carrier, stacking effect, arbutin, doxorubicin

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Article Details

Year: 2006
Page: [188 - 191]
Pages: 4
DOI: 10.2174/157018006776286925
Price: $58