Synthesis and Evaluation of Hypolipidemic Properties of some Novel Derivatives of Thieno Oxazine and 5-Hydroxyindole-2-Carboxylic Acid

Author(s): Sankar Mohan , K. A. Reddy , Javed Iqbal , Debnath Bhuniya , Saibal K. Das .

Journal Name: Letters in Drug Design & Discovery

Volume 3 , Issue 3 , 2006

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Abstract:

Two series of molecules were synthesized with carboxamidomethyl linker utilizing thieno oxazine and 5-Hydroxyindole-2-carboxylic acid. In vivo studies of these molecules indicated that molecules from each series, 4h and 5b, are very potent triglyceride lowering agents.

Keywords: Synthesis, thieno oxazine, indole carboxylic acid, hypolipidemic properties, triglyceride

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Article Details

VOLUME: 3
ISSUE: 3
Year: 2006
Page: [179 - 182]
Pages: 4
DOI: 10.2174/157018006776287014
Price: $58