HIF-1α as a Target for Drug Design in Ischemic Injury: Effect of Cobalt Treatment on Mitochondrial DNA Damage in Cells Exposed to H2O2

Author(s): Yasutomo Nomura , Hiroyuki Fujiwara , Kohei Ito , Hirobumi Fuchigami , Michihiko Sato , Eiji Takahashi , Yasukazu Hozumi , Kaoru Goto , Zhonggang Feng , Takao Nakamura .

Journal Name: Letters in Drug Design & Discovery

Volume 3 , Issue 3 , 2006

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Abstract:

Severity of ischemia/reperfusion injury accompanied with generation of reactive oxygen species is reduced by hypoxic preconditioning, the precise mechanisms of which are not completely understood. We found that cobalt-induced hypoxia-inducible factor-1α activity ameliorated suppression of cell growth caused by H2O2 through protecting mitochondrial DNA from oxidative damage.

Keywords: HIF-1α, cobalt, H2O2, cell growth, mitochondria, DNA damage

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Article Details

VOLUME: 3
ISSUE: 3
Year: 2006
Page: [172 - 174]
Pages: 3
DOI: 10.2174/157018006776286952
Price: $58