Regulation of MMP/TIMP Balance as Therapeutic Target in Pulmonary Diseases

Author(s): Corinne A.E. Martin-Chouly , Stephanie Guillot , Stephane Jouneau , Sylvie Caulet-Maugendre , Laurent Vernhet , Vincent Lagente , Philippe Delaval .

Journal Name: Letters in Drug Design & Discovery

Volume 3 , Issue 3 , 2006

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Abstract:

Matrix metalloproteinases (MMPs) are a family of zinc endopeptidases, regulated by endogenous tissue inhibitors (TIMPs) and inducer (EMMPRIN). The demonstration of a functional role of MMPs in pulmonary diseases raises the possibility of therapeutic intervention targeting MMP/TIMP balance to prevent pathological processes.

Keywords: Pulmonary diseases, MMP, TIMP, EMMPRIN, regulation

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Article Details

VOLUME: 3
ISSUE: 3
Year: 2006
Page: [159 - 171]
Pages: 13
DOI: 10.2174/157018006776287005
Price: $58