Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Regulation of MMP/TIMP Balance as Therapeutic Target in Pulmonary Diseases

Author(s): Corinne A.E. Martin-Chouly, Stephanie Guillot, Stephane Jouneau, Sylvie Caulet-Maugendre, Laurent Vernhet, Vincent Lagente, Philippe Delaval.

Abstract:

Matrix metalloproteinases (MMPs) are a family of zinc endopeptidases, regulated by endogenous tissue inhibitors (TIMPs) and inducer (EMMPRIN). The demonstration of a functional role of MMPs in pulmonary diseases raises the possibility of therapeutic intervention targeting MMP/TIMP balance to prevent pathological processes.

Keywords: Pulmonary diseases, MMP, TIMP, EMMPRIN, regulation

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Article Details

VOLUME: 3
ISSUE: 3
Year: 2006
Page: [159 - 171]
Pages: 13
DOI: 10.2174/157018006776287005
Price: $58