Pt(II) vs Pd(II) Polyamine Complexes as New Anticancer Drugs: A Structure- Activity Study

Author(s): S. M. Fiuza , A. M. Amado , Paulo J. Oliveira , Vilma A. Sardao , L. A.E.B. de Carvalho , M. P.M. Marques .

Journal Name: Letters in Drug Design & Discovery

Volume 3 , Issue 3 , 2006

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Abstract:

Two homologous trinuclear polyamine chelates with either Pt(II) (Ia) or Pd(II) (Ib) were screened for their anticancer properties. Their growth-inhibition activity towards a human tongue epithelioma (HSC-3) was assessed in vitro, and the effect of the cation alteration was determined (IC50 =32 μM for Ib vs 66 μM for Ia).

Keywords: Pt(II), Pd(II), spermidine, anticancer drugs, squamous tongue epithelioma

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Article Details

VOLUME: 3
ISSUE: 3
Year: 2006
Page: [149 - 151]
Pages: 3
DOI: 10.2174/157018006776286989
Price: $58

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