Pt(II) vs Pd(II) Polyamine Complexes as New Anticancer Drugs: A Structure- Activity Study
S. M. Fiuza,
A. M. Amado,
Paulo J. Oliveira,
Vilma A. Sardao,
L. A.E.B. de Carvalho,
M. P.M. Marques.
Two homologous trinuclear polyamine chelates with either Pt(II) (Ia) or Pd(II) (Ib) were screened for their anticancer properties. Their growth-inhibition activity towards a human tongue epithelioma (HSC-3) was assessed in vitro, and the effect of the cation alteration was determined (IC50 =32 μM for Ib vs 66 μM for Ia).
Keywords: Pt(II), Pd(II), spermidine, anticancer drugs, squamous tongue epithelioma
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