Protein & Peptide Letters

Prof. Ben M. Dunn  
Department of Biochemistry and Molecular Biology
University of Florida
College of Medicine
P.O. Box 100245
Gainesville, FL
USA
Email: bdunn@ufl.edu

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Amyloid Under the Atomic Force Microscope

Author(s): Walraj S. Gosal, Sarah L. Myers, Sheena E. Radford, Neil H. Thomson.

Abstract:

The atomic force microscope (AFM) is a versatile instrument that can be used to image biological samples at nanometre resolution as well as to measure inter and intra-molecular forces in air and liquid environments. This review summarises the use of AFM applied to protein and peptide self-assembly systems involved in amyloid formation. The technical principles of the AFM are outlined and its advantages and disadvantages are highlighted and discussed in the context of the rapidly developing field of amyloid research.

Keywords: Tapping mode, contact mode, functional surfaces, time-lapse microscopy, 3D topography, self-assembly, amyloid fibrils, biomimetic environments

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Article Details

VOLUME: 13
ISSUE: 3
Year: 2006
Page: [261 - 270]
Pages: 10
DOI: 10.2174/092986606775338498
Price: $58