Abstract
Quasielastic light scattering spectroscopy (QLS) is an optical method for the determination of diffusion coefficients of particles in solution. Here we discuss the principles of QLS and explain how the distribution of particle sizes can be reconstructed from the measured correlation function of scattered light. Non-invasive observation of the temporal evolution of particle sizes provides a powerful tool for studying protein assembly. We illustrate practical applications of QLS with examples from studies of fibril formation of the amyloid β-protein.
Keywords: Alzheimer's disease, amyloid β-protein, aggregation, fibril formation, quasielastic light scattering, regularization, elongation, nucleation
Protein & Peptide Letters
Title: Quasielastic Light Scattering Study of Amyloid β-Protein Fibril Formation
Volume: 13 Issue: 3
Author(s): Aleksey Lomakin and David B. Teplow
Affiliation:
Keywords: Alzheimer's disease, amyloid β-protein, aggregation, fibril formation, quasielastic light scattering, regularization, elongation, nucleation
Abstract: Quasielastic light scattering spectroscopy (QLS) is an optical method for the determination of diffusion coefficients of particles in solution. Here we discuss the principles of QLS and explain how the distribution of particle sizes can be reconstructed from the measured correlation function of scattered light. Non-invasive observation of the temporal evolution of particle sizes provides a powerful tool for studying protein assembly. We illustrate practical applications of QLS with examples from studies of fibril formation of the amyloid β-protein.
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Cite this article as:
Lomakin Aleksey and Teplow B. David, Quasielastic Light Scattering Study of Amyloid β-Protein Fibril Formation, Protein & Peptide Letters 2006; 13 (3) . https://dx.doi.org/10.2174/092986606775338515
DOI https://dx.doi.org/10.2174/092986606775338515 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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