Antibiotics which Target the Wolbachia Endosymbionts of Filarial Parasites: A New Strategy for Control of Filariasis and Amelioration of Pathology

Author(s): K. M. Pfarr, A. M. Hoerauf.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 6 , Issue 2 , 2006

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Abstract:

Wolbachia endosymbionts of filariae are targets for the development of new antifilarial chemotherapy. Doxycycline to deplete Wolbachia from the worm has demonstrated the feasibility of this strategy and has provided a new chemotherapeutic tool. Recent research shows that depleting Wolbachia will also lessen pathology, and lessen adverse reactions to traditional antifilarial drugs.

Keywords: Lymphatic filariasis, onchocerciasis, Wolbachia, tetracycline, doxycycline

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Article Details

VOLUME: 6
ISSUE: 2
Year: 2006
Page: [203 - 210]
Pages: 8
DOI: 10.2174/138955706775475984
Price: $58

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