Interference with Redox-Active Enzymes as a Basis for the Design of Antimalarial Drugs

Author(s): S. Rahlfs, K. Becker.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 6 , Issue 2 , 2006

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Abstract:

Antimalarial drugs are urgently and continuously required. Parasite enzymes involved in antioxidant defence represent interesting target molecules for rational drug development. Here we summarize the currently available data on structural, biochemical, and functional properties of these proteins in an attempt to evaluate and compare their potential as drug targets.

Keywords: Plasmodium, drug development, redox metabolism, thioredoxin, glutathione, structure, target validation, malaria

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Article Details

VOLUME: 6
ISSUE: 2
Year: 2006
Page: [163 - 176]
Pages: 14
DOI: 10.2174/138955706775475911
Price: $58