Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Synthesis and Trypanocidal Evaluation of News 5-[N-(3-(5-Substituted)- 1,3,4-Thiadiazolyl)]Amino-1-Methyl-4-Nitroimidazoles

Author(s): A. S. Carvalho, D. Gibaldi, A. C. Pinto, M. Bozza, N. Boechat.

Abstract:

A new series of 5-[N-(3-(5-substituted)-1,3,4-thiadiazolyl)]amino-1-methyl-4-nitroimidazoles (6ah) has been designed, synthesized and examined for their ability against Trypanosoma cruzi. The compounds were prepared by nucleophilic aromatic substitution. Several bases were investigated as proton scavengers, and lithium diisopropylamide (LDA) was found to be the best base giving products in good yields.

Keywords: 1,3,4-thiadiazole derivative, nucleophilic aromatic substitution, megazol, trypanocidal activity

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Article Details

VOLUME: 3
ISSUE: 2
Year: 2006
Page: [98 - 101]
Pages: 4
DOI: 10.2174/157018006775789667
Price: $58