Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Synthesis and Antitumor Activity of 20-O-Linked Succinate-Based Camptothecin Ester Derivatives

Author(s): Hua Lu, Haixia Lin, Yi Jiang, Xinguang Zhou, Beili Wu, Jianmin Chen.

Abstract:

A series of new 20-O-linked succinate-based camptothecin ester derivatives were synthesized and their cytotoxicities were tested on five human cancer cell lines by MTT assay. All the derivatives showed moderate antitumor activity in vitro, and they were 20-to-several thousand-fold less toxic than their parent drug.

Keywords: Camptothecin, ester, succinate, prodrug, antitumor

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Article Details

VOLUME: 3
ISSUE: 2
Year: 2006
Page: [83 - 86]
Pages: 4
DOI: 10.2174/157018006775789757
Price: $58