Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Synthesis and Evaluation of Aminoglycosides as Inhibitors for Rev binding to Rev Responsive Element

Author(s): Hayamitsu Adachi, Yoshinori Takahashi, Motoki Kyo, Tsuyoshi Sato, Yoshio Nishimura.

Abstract:

Interactions of α-amino or guanidino-α-hydroxybutyryl-aminoglycosides with an essential sequence of Rev responsive element (RRE) in HIV-1 mRNA were evaluated using surface plasmon resonance imaging. Aminoglycosides were proved to bind nonspecifically to RRE.

Keywords: Aminoglycoside, surface plasmon resonance imaging, RNA recognition

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Article Details

VOLUME: 3
ISSUE: 2
Year: 2006
Page: [71 - 75]
Pages: 5
DOI: 10.2174/157018006775789694
Price: $58