Computational Prediction of Functionally Important Regions in Proteins

Author(s): Florencio Pazos , Jung-Wook Bang .

Journal Name: Current Bioinformatics

Volume 1 , Issue 1 , 2006

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Current projects for the massive characterization of proteomes are generating protein sequences and, to less extent, three dimensional structures with unknown function. Experimentally determining functional features of a protein is expensive, time consuming and difficult to automate. There is therefore a demand for computational methods for predicting protein functional features, which can be coupled to the pipelines of genome sequencing and structure determination. This review focuses on current in-silico methods for predicting regions in proteins with some functional importance (catalytic sites, binding sites, protein interaction regions, etc.) using sequence and/or three-dimensional structure information.

Keywords: Functional site, active site, binding site, protein function, protein interaction

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Article Details

Year: 2006
Page: [15 - 23]
Pages: 9
DOI: 10.2174/157489306775330633

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PDF: 10