Glycine Transporter Inhibitors as Therapeutic Agents for Schizophrenia

Author(s): Kenji Hashimoto.

Journal Name: Recent Patents on CNS Drug Discovery (Discontinued)

Volume 1 , Issue 1 , 2006

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Abstract:

Multiple lines of evidence suggest that a dysfunction in the glutamatergic neurotransmission via the N-methyl- D-aspartate (NMDA) receptors contributes to the pathophysiology of psychiatric diseases including schizophrenia. The potentiation of NMDA receptor function may be a useful approach for the treatment of diseases associated with NMDA receptor hypofunction. One possible strategy is to increase synaptic levels of glycine by blocking the glycine transporter-1 (GlyT-1) in glia cells, since glycine acts as a co-agonist site on the NMDA receptor. In this article, the author reviews the recent important patents on GlyT-1 inhibitors for treatment of schizophrenia and other psychiatric diseases associated with the NMDA receptor hypofunction.

Keywords: NMDA receptor, glycine, glycine transporter, glia, cognition, schizophrenia

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Article Details

VOLUME: 1
ISSUE: 1
Year: 2006
Page: [43 - 53]
Pages: 11
DOI: 10.2174/157488906775245336

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