Glycine Transporter Inhibitors as Therapeutic Agents for Schizophrenia
Affiliation: Division of ClinicalNeuroscience, Chiba University Center for Forensic Mental Health, 1-8-1Inohana, Chiba 260-8670, Japan;
Keywords: NMDA receptor, glycine, glycine transporter, glia, cognition, schizophrenia
Multiple lines of evidence suggest that a dysfunction in the glutamatergic neurotransmission via the N-methyl- D-aspartate (NMDA) receptors contributes to the pathophysiology of psychiatric diseases including schizophrenia. The potentiation of NMDA receptor function may be a useful approach for the treatment of diseases associated with NMDA receptor hypofunction. One possible strategy is to increase synaptic levels of glycine by blocking the glycine transporter-1 (GlyT-1) in glia cells, since glycine acts as a co-agonist site on the NMDA receptor. In this article, the author reviews the recent important patents on GlyT-1 inhibitors for treatment of schizophrenia and other psychiatric diseases associated with the NMDA receptor hypofunction.
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