Current Stem Cell Research & Therapy

Anthony Atala  
Wake Forest University School of Medicine,
Medical Center Boulevard
Winston Salem, NC 27157


Intracellular Signaling Pathways Regulating Pluripotency of Embryonic Stem Cells

Author(s): Keisuke Okita and Shinya Yamanaka

Affiliation: Department of Stem CellBiology, Institute for Frontier Medical Sciences, Kyoto University, 53Kawahara-machi, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan;

Keywords: Growth factor, Cytokine, Regenerative medicine, Transcription factor, Crosstalk


The cytokine LIF and its downstream effector STAT3 are essential for maintenance of pluripotency in mouse ES cells. The requirement for the transcription factor Oct3/4 for ES cell pluripotency is also welldocumented. However, LIF is not involved in self-renewal of human ES cells, suggesting that other pathways must play an important role in this process. The importance of other signal transduction pathways, including BMP and Wnt signalings, as well as novel transcription factors such as Nanog, is now being recognized. We will review the rapid progress that has been made in identifying and dissecting the intracellular signaling pathways that contribute to self-renewal of pluripotent mouse and human ES cells.

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Article Details

Page: [103 - 111]
Pages: 9
DOI: 10.2174/157488806775269061