Synthesis and Evaluation of Anthelmintic and Cytotoxic Properties of Bis- 1,3-Azole Analogs of Natural Products
Tandem cyclizations to [2,5] bis-1,3-azoles provided simplified and stable models of biological active marine natural products. The cytotoxic activity in HCT-15 cells and the effect on the L4 larvae of Nippostrongylus brasiliensis of the heterocycles were evaluated and provided data that serve for the preparation of bioselective new therapeutic agents.
Keywords: Bis-1,3-azoles, anthelmintic, cytotoxic, Bengazoles
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