Benzodiazepine based heterocycles can be prepared efficiently on solid-support by employing different approaches. In this review, an effort has been made to highlight academic and industrial examples of combinatorial synthesis for this type of heterocycles published in the last decade. Therefore, it describes synthetic strategies for the generation of benzodiazepine privileged structures employing the corresponding resin-bound substrates. Further, the most relevant biological properties of these heterocycles have also been incorporated.
Keywords: heterocycles, cyclocondensation, combinatorial library, peptidomimetics, 4,5-dihydro-1H-1,4-benzodiazepine-2,3-diones, one-pot elimination-cyclization
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