Solid-Phase Synthesis of Biologically Interesting Compounds Containing Hydroxamic Acid Moiety

Author(s): Viktor Krchnak.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 6 , Issue 1 , 2006

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Chemical strategies developed for the solid-phase synthesis of hydroxamates are divided into four groups: (i) the traditional synthesis of hydroxamates via cleavage of resin-bound esters by hydroxylamine and its derivatives, (ii) introduction of hydroxamic acid moiety on the resin-bound precursor, (iii) transformation of polymer-supported hydroxylamine, attached to a solid supported linker either by oxygen (O-linking strategy) or by nitrogen (N-linking strategy), and (iv) synthesis of N-alkyl hydroxamates. The scope and limitation of individual approaches are discussed.

Keywords: Hydroxamic acid, hydroxamate, solid-phase synthesis

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Article Details

Year: 2006
Page: [27 - 36]
Pages: 10
DOI: 10.2174/138955706775197811

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