Solid-Phase Synthesis in the Twenty-First Century

Author(s): A. Ganesan .

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 6 , Issue 1 , 2006

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Abstract:

Solid-phase synthesis is a powerful tool for achieving high-throughput chemistry. This review discusses recent diverse examples from my group: the solid-phase synthesis of unsymmetrical guanidines, polymer-supported versions of cyclooctadiene and 9-BBN, a triflate-like linker, the synthesis of tetrahydro-β-carbolines by the acyliminium Pictet-Spengler reaction, and a total synthesis of the antimycobacterial cyclic depsipeptide natural product kahalalide A.

Keywords: Solid-phase synthesis, combinatorial chemistry, guanidines, polymer-supported reagents, traceless cleavage, alkaloids, Pictet-Spengler reaction, depsipeptides

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Article Details

VOLUME: 6
ISSUE: 1
Year: 2006
Page: [3 - 10]
Pages: 8
DOI: 10.2174/138955706775197866

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