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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Biological Activity of Cytokines: An Evolutionary Perspective

Author(s): G. Scapigliati, F. Buonocore and M. Mazzini

Volume 12, Issue 24, 2006

Page: [3071 - 3081] Pages: 11

DOI: 10.2174/138161206777947489

Price: $65

Abstract

It appears evident that teleost fish are at present the vertebrate group in which, excluding mammals, most information on the immune system is available. However, despite the great impetus on the discovery of genes homologous to mammalian immunomodulatory molecules, the knowledge on biological activities exerted by cytokines is meager. This review reports the present knowledge on the biological activities of cytokine-like and cytokines in invertebrates and coldblooded vertebrates.

Keywords: Cytokine, Bioactivity, Evolution, Fish immunology, Teleost, IL-1


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