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Current Pharmaceutical Design
ISSN (Print): 1381-6128
ISSN (Online): 1873-4286
VOLUME: 12
ISSUE: 24
DOI: 10.2174/138161206777947551      Price:  $58









Innate Immunity in Lophotrochozoans: The Annelids

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Author(s): Michel Salzet, Aurelie Tasiemski and Edwin Cooper
Pages 3043-3050 (8)
Abstract:
Innate immunity plays a major role as a first defense against microbes. Effectors of the innate response include pattern recognition receptors (PRR), phagocytic cells, proteolytic cascades and peptides/proteins with antimicrobial properties. Each element of these events has been well studied in vertebrates and in some invertebrates such as annelids. From these different researches, it appears that mammalian innate immunity could be considered as a mosaic of invertebrate immune responses. Annelids belonging to the lophotrochozoans group are primitive coelomates that possess specially developed cellular immunity against pathogens including phagocytosis, encapsulation and spontaneous cytotoxicity of coelomocytes against allogenic or xenogenic cells. They have also developed an important humoral immunity that is based on antimicrobial, hemolytic and clotting properties of their body fluid. In the present review, we will emphasize the different immunodefense strategies that adaptation has taken during the course of evolution of two classes of annelids i.e. oligochaetes and achaetes.
Keywords:
CD markers, coelomic cytolytic factor (CCF), Antimicrobial Peptides, Cytokines, Serine Protease Inhibitors
Affiliation:
Laboratoire de NeuroImmunologie des Annelides, UMR CNRS 8017, SN3, Universite des Sciences et Technologies de Lille, 59655 Villeneuve d'Ascq Cedex, France.