Hematopoietic Cell Formation in Leech Wound Healing

Author(s): A. Grimaldi, G. Tettamanti, G. Perletti, R. Valvassori, M. de Eguileor.

Journal Name: Current Pharmaceutical Design

Volume 12 , Issue 24 , 2006

Submit Manuscript
Submit Proposal

Abstract:

The angiogenic process in vertebrates and hirudineans has been compared. The leech Hirudo medicinalis, subjected to an angiogenic stimulus (surgical explant or cytokine treatment) responds, as a vertebrate, with the formation of an extensive network of new vessels accompanied by the production of circulating cells. The reviewed data confirm the surprising similarity between hirudinean and vertebrate processes in wound healing, and suggest that basic common events such as antigenic expressions of endothelial and hemopoietic cells, cytokine secretion and regulation as well as extracellular matrix interactions, are conserved and extended across diverse species, tissues and developmental phases.

Keywords: Angiogenesis, hematopoietic cells, leeches, cytokines

Rights & PermissionsPrintExport Cite as


Article Details

VOLUME: 12
ISSUE: 24
Year: 2006
Page: [3033 - 3041]
Pages: 9
DOI: 10.2174/138161206777947443
Price: $58

Article Metrics

PDF: 1