Current Organic Chemistry

Atta-ur-Rahman , FRS
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK

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Transition Metal-Catalyzed Intramolecular Enyne Cyclization Reaction

Author(s): Z. Zhang, G. Zhu, X. Tong, F. Wang, X. Xie, J. Wang, L. Jiang.

Abstract:

This review summarizes the recent developments in transition metal-catalyzed 1,n-enyne cyclization reactions that have been reported in the literature from January 1, 2002 to April 30, 2005. The cyclizations described herein include four parts according the reaction mechanism, i. e. cyclization initiated by oxidative cyclometallation; by activation of the triple bond to form a vinyl metal species; by electrophilic activation of the triple bond; and by activation of the double bond. Enyne cyclizations that do not follow the above reaction mechanism are not included.

Keywords: E-double bond, electrophilic activation, five-membered ring products, cycloisomerization, phosphine l igands

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Article Details

VOLUME: 10
ISSUE: 12
Year: 2006
Page: [1457 - 1478]
Pages: 22
DOI: 10.2174/138527206778018203
Price: $58