Abstract
The cellular prion protein (PrPc) is a protein found on the cell surface of many cell subtypes, especially neurons, anchored by a glycosyl-phosphatidylinositol residue. The physiological role of PrPc is still not understood. However, it is known that participates in copper uptake, protection against oxidative stress, cell adhesion, differentiation, signalling and cell survival. Moreover, it is also involved in memory formation. Despite the numerous functions given to PrPc, its discovery did not occur due to its altered isoform involvement (PrPsc) as an infectious agent of spongiform encephalopathies These diseases are unique because they can be hereditary, sporadic or have an acquired etiology. Much has been done concerning this intriguing protein, but there is still the need for more studies to truly understand PrPc functions and PrPsc pathogenesis mechanisms. In this way, new and more effective therapeutichal approaches can be developed, and more information on other amyloid diseases can be gathered.
Keywords: Cellular prion protein, prion protein, physiological function, prion diseases, transmissible spongiform encephalopathies, neurodegeneration, oxidative stress, signaling pathways
Current Neurovascular Research
Title: Implications of Prion Protein Biology
Volume: 3 Issue: 3
Author(s): Vinícius Pieta Perez and Adriana Simon Coitinho
Affiliation:
Keywords: Cellular prion protein, prion protein, physiological function, prion diseases, transmissible spongiform encephalopathies, neurodegeneration, oxidative stress, signaling pathways
Abstract: The cellular prion protein (PrPc) is a protein found on the cell surface of many cell subtypes, especially neurons, anchored by a glycosyl-phosphatidylinositol residue. The physiological role of PrPc is still not understood. However, it is known that participates in copper uptake, protection against oxidative stress, cell adhesion, differentiation, signalling and cell survival. Moreover, it is also involved in memory formation. Despite the numerous functions given to PrPc, its discovery did not occur due to its altered isoform involvement (PrPsc) as an infectious agent of spongiform encephalopathies These diseases are unique because they can be hereditary, sporadic or have an acquired etiology. Much has been done concerning this intriguing protein, but there is still the need for more studies to truly understand PrPc functions and PrPsc pathogenesis mechanisms. In this way, new and more effective therapeutichal approaches can be developed, and more information on other amyloid diseases can be gathered.
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Cite this article as:
Pieta Perez Vinícius and Simon Coitinho Adriana, Implications of Prion Protein Biology, Current Neurovascular Research 2006; 3 (3) . https://dx.doi.org/10.2174/156720206778018785
DOI https://dx.doi.org/10.2174/156720206778018785 |
Print ISSN 1567-2026 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5739 |
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