Biocatalysis: Synthesis of Chiral Intermediates for Pharmaceuticals

Author(s): Ramesh N. Patel.

Journal Name: Current Organic Chemistry

Volume 10 , Issue 11 , 2006

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Abstract:

The production of single enantiomers of drug intermediates has become increasingly important in the pharmaceutical industry. Chiral intermediates and fine chemicals are in high demand by both the pharmaceutical and agrochemical industries for the preparation of bulk drug substances and agricultural products. The enormous potential of microorganisms and enzymes for the transformation of synthetic chemicals with high chemo-, regio- and enatioselectivities has been demonstrated. In this article, biocatalytic processes are described for the synthesis of chiral intermediates for anti-hypertensive drugs, lipid lowering drugs, anti-cancer agents, antiviral agents, β-3- and β-2-receptor receptor agonists, melatonin receptor agonists, a tryptase inhibitor, retinoic acid γ-specific antagonist, and anti-

Keywords: HIV Protease Inhibitor, Enzymatic Synthesis, biotransformation, Crixivan, Aminoacylation, Paclitaxel, Orally Active Taxane

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Article Details

VOLUME: 10
ISSUE: 11
Year: 2006
Page: [1289 - 1321]
Pages: 33
DOI: 10.2174/138527206777698011
Price: $58

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